Cyclic GMP-AMP synthase deficiency predisposes the liver to alcohol-induced cell death and ER stress.

Hepatol Commun · 2026 · PMC12922916 · PMID 41730234

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an increasing trendno p-value reported

Similarly, we observed an increasing trend in TUNEL + cells in WT mice administered with alcohol and cGAS inhibitor as compared with alcohol alone and water alone, suggesting increased apoptosis after alcohol administration in WT and cGAS-KO mice.

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