Targeting Metabolic Vulnerabilities in Glioblastoma: a Framework for Multi-node Combination Therapy.

Curr Oncol Rep · 2026 · PMC12923475 · PMID 41718834

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not as significantno p-value reported

Additionally, PPAT depletion is an alternative therapeutic target and decreases GBM cell growth [ 94 ], although glutamine’s contributions to nucleotide synthesis are not as significant as its anaplerotic and antioxidant contributions [ 92 ].

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