highly significantP < 0.001
* P < 0.05 was considered statistically significant, ** P < 0.01 as highly significant, *** P < 0.001 as very highly significant, and **** P < 0.0001 as extremely significant.
* P < 0.05 was considered statistically significant, ** P < 0.01 as highly significant, *** P < 0.001 as very highly significant, and **** P < 0.0001 as extremely significant.