Circulating S100A8/A9 drives faster platelet COX-1 recovery via MRP4, impairing the duration of aspirin response.

Blood Adv · 2026 · PMC12925102 · PMID 41295984

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0.0980

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a nonsignificant trendP = .098so close (0.05 < p ≤ 0.1)

rS100A8/A9 may promote the transfer of miR-21-5p from platelets to the circulation via MRP4 in DAMI cells Stimulation of DAMI cells with rS100A8/A9 significantly decreased intracellular miR-21-5p levels at 1 hour ( P = .020) and 3 hours ( P = .009), compared with baseline (0 hour; Figure 6 A), with a nonsignificant trend for an increase of miR-21-5p levels in the supernatant at 12 hours ( P = .098; Figure 6 D).

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