Hippocampal expression of Wnt7a and β-catenin in depression: evidence from chronic unpredictable mild stress.

In the dentate gyrus (DG), a highly significant interaction was found (F(1,8) = 883.0, p < 0.0001), reflecting a differential upregulation where β-catenin increased more profoundly (mean difference = 53.31%, 95% CI [52.31%–54.31%], Cohen’s d = 106.2) than Wnt7a (mean difference = 38.03%, 95% CI [37.03%–39.03%], Cohen’s d = 99.9).

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