ICU-ROX demonstrated substantial subgroup variation: patients with hypoxic-ischemic encephalopathy (HIE) showed a numerical trend favoring conservative oxygen therapy (180-day mortality 43% vs. 59%, relative risk=0.73), whereas patients with sepsis experienced lower mortality with liberal oxygen therapy (180-day mortality 33.1% vs . 36.2%).
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Beyond one-size-fits-all: Addressing patient heterogeneity through precision-based oxygen therapy research in critical care.
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