Acute inflammation and fronto-striatal connectivity in the transition from acute to persistent fatigue after mild COVID-19: A longitudinal fMRI study.

In contrast, the direct path from CRP to chronic fatigue became marginally significant (effect = 0.083, P = 0.065) after including the mediators, indicating that the influence of early inflammation is predominantly mediated through acute fatigue and its downstream effect on brain network integrity ( Fig. 5 D– Supplementary Table 3 ). 4 Discussion To our knowledge, we conducted the first investigation into the neurobiological mechanisms underlying the onset and progression of post-COVID fatigue within a large-scale longitudinal cohort.

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