Safety and pharmacokinetics of a novel potent GABA analogue crisugabalin in Chinese subjects with various degrees of renal impairment.

C max showed an increasing trend with declining renal function, although no significant differences were observed compared to the normal renal function group.

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The CL R for subjects with normal renal function, mild, moderate and severe renal impairment were 7.91, 7.31, 3.73 and 1.80 L/h, respectively, showing a decreasing trend with the increasing severity of renal impairment.

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