<b>Simulated</b> microgravity induces cerebral dysfunction by disturbing protective microbiota-metabolite-microglia signaling across the gut‒brain ax<b>is</b>.

However, the LA levels showed a decreasing trend but remained unchanged post-SMG exposure, the imprecise quantification inherent to untargeted sequencing required confirmation by targeted metabolite detection, which definitively validated the downregulation of LA and its derivatives ( Figure 4F ).

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