Lower hippocampal volume partly mediates the association between rs6859 in the <i>NECTIN2</i> gene and Alzheimer's disease: new findings from causal mediation analysis of ADNI data.

Discussion Our results indicate that hippocampal atrophy may mediate the association between NECTIN2 polymorphism and AD risk, although the borderline significance of these associations warrants confirmation in other populations.

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For these reasons, reduced statistical power may have influenced the results, leading to borderline significant p -values.

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