Barely Significant
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Silencing of the Metabolic Gene HKDC1 Is Associated With Aging and Neurodegeneration in Mice and Humans.

Aging Cell · 2026 · PMC12932916 · PMID 41736382

Europe PMCDOI
2
hedged sentences
0.0700
closest p · 1.4× alpha
0.0700
boldest claim

The sentences

marginal significancep = 0.07so close (0.05 < p ≤ 0.1)
Genetically predicted brain HKDC1 protein abundance conferred a potentially protective effect against AD, with marginal significance in a meta‐analysis of two independent AD GWAS datasets (OR: 0.51, 95% CI: 0.23–1.12; p = 0.07) (Figure 1A,B ).

also in 5,069 other papers

highly significantno p-value reported
Uncovering the genes that play a role in the metabolic regulation of NDD is, therefore, highly significant.

also in 132,142 other papers

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