Lamin B receptor upregulation in metastatic melanoma causes nuclear envelope fragility in confined migration during cancer invasion.

Proc Natl Acad Sci U S A · 2026 · PMC12933115 · PMID 41706894

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Principal component analysis (PCA) of an RNA-seq transcriptomic dataset (GEO: GSE98394 ) from bulk tumor biopsies identified a highly significant separation of components between benign nevi and metastatic melanoma, indicating melanoma progression from early to aggressive is a clear transcriptional evolution ( Fig. 2 A and SI Appendix , Fig.

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