Chronic intermittent hypoxia reshapes circadian metabolic architecture in a model of sleep apnea.

Sci Adv · 2026 · PMC12935056 · PMID 41739942

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a weak trendno p-value reported

However, CREB1 phosphorylation exhibited distinct temporal dynamics: While a weak trend was observed in control animals (ZT8 to ZT12), a pronounced circadian peak emerged under IH between ZT0 and ZT8, aligning with the hypoxic phase ( Fig. 4D ).

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