Key cancer‐associated pathways, including G2/M checkpoint regulation, E2F targets, mitotic spindle assembly, and estrogen signaling, were consistently enriched and highly significant (as indicated with same‐colored arrows in each subpanel). 3.2 Colon cancer DEGs reveal hallmarks of cell cycle and metabolic program in cancer samples Major cellular biological processes (see Section 2 ) cover the preselected 50 gene sets (MSigDB).
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Patient-specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity.
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