Target Fidelity and Failure: Structure-Activity Relationship of High-Molecular-Mass Penicillin-Binding Proteins (HMM-PBPs) in Refractory <i>Granulicatella adiacens</i> Endocarditis.

Antibiotics (Basel) · 2026 · PMC12937247 · PMID 41750466

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highly significantp < 0.0001actually significant

Statistical analysis of the IC 50 values for all essential PBPs demonstrated a highly significant reduction in drug affinity in the IS 48 clinical isolate compared with the ATCC 49175 reference strain ( p < 0.0001).

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Target Fidelity and Failure: Structure-Activity Relationship of High-Molecular-Mass Penicillin-Binding Proteins (HMM-PBPs) in Refractory &lt;i&gt;Granulicatella adiacens&lt;/i&gt; Endocarditis.

The sentences

Target Fidelity and Failure: Structure-Activity Relationship of High-Molecular-Mass Penicillin-Binding Proteins (HMM-PBPs) in Refractory <i>Granulicatella adiacens</i> Endocarditis.