Telomeric Ends and Telomerase-Canonical and Non-Canonical Roles in Breast Cancer Tumorigenesis and Therapy Resistance.

Biomedicines · 2026 · PMC12937728 · PMID 41751213

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Through these mechanisms, hTERT plays an essential role in maintaining mitochondrial homeostasis, which may be significant in the context of cancer, neurodegenerative diseases, or infertility treatment [ 88 ]. hTERT contributes to drug resistance in cancer cells by protecting mitochondrial DNA and reducing oxidative stress, thereby promoting cell survival.

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