Three Polyphenolic Compounds from <i>Inonotus obliquus</i>: Antioxidant Activity, Xanthine Oxidase Inhibition, and Regulatory Effects on MyD88/TLR4/NF-κB Pathway in MSU-Induced RAW 264.7 Macrophages.

Protective Effects of Polyphenols in the Acute Gout Cell Model As shown in Figure 6 , the cell viability was highly and significantly reduced to 59.93 ± 4.32% when MSU was added up to a concentration of 150 μg/mL compared to the control group, and the cell viability was significant or highly significant after the addition of 12.5, 25, and 50 μg/mL I. obliquus extract, 2.5, 5, and 10 μM PAH, 12.5, 25, and 50 μM PA, and 2.5, 5, and 10 μM OS compared to the model group, respectively.

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