Mitochondrial Resilience in Glaucoma: Targeting NAD<sup>+</sup> Metabolism and Oxidative Stress in Retinal Ganglion Cell Degeneration with Nicotinamide Riboside and Berberine: Preliminary Clinical Evidence.

Comparing pre- and post-treatment conditions, Student’s t -test demonstrated a highly significant difference ( p = 3.13 × 10 −10 ), strongly supporting the hypothesis of treatment-related improvement.

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A subset of patients, whom we termed “responders”, also showed a positive trend of increased RNFL thickness on OCT, or at least a halt in RNFL thinning, compared with pre-treatment measurements.

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