highly significantp < 0.001
Kaplan–Meier analysis revealed pronounced survival differences, with CON4 and CON1 showing highly significant log-rank tests ( p < 0.001 for both), where high-activity groups had substantially shorter median survival (32.4 vs. 65.5 months for CON4; 30.5 vs. 56.6 months for CON1) ( Figure 4 E,F).