While we could not use specific concentrations for all the metabolites involved in the nine pathways mentioned above, the list of metabolites we obtained from these two studies are highly significant metabolites such as ATP, Adeniosine Diphosphate, and various amino acids such as arginine, glutamate, and proline that play crucial roles in metabolism and immune response and were also identified as bottlenecks by our shadow price analysis.
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Pathway thermodynamic analysis postulates change in glutamate metabolism as a key factor in modulating immune responses.
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