Integrative Vitamin D-Inflammatory-Coagulation Biomarker Index Predicts COVID-19 Severity: Development and Validation of the Vitamin D Inflammatory Burden Score (VDIBS).

Int J Mol Sci · 2026 · PMC12940731 · PMID 41751905

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highly significantp = 0.008actually significant

+ Vitamin D Tier (Full VDIBS): AUC 0.78 (95% CI 0.73–0.81) ○ Incremental benefit: ΔAUC = +0.05 (95% CI +0.02 to +0.08, p = 0.004); ○ Likelihood ratio test: χ 2 (1 df) = 8.4, p = 0.004 (highly significant); ○ Net Reclassification Improvement: NRI = 0.12 ( p = 0.008); ○ Integrated Discrimination Improvement: IDI = 4.2% ( p = 0.012).

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