Systematic Review of Non-Coding Genomic Variants in Globin and Non-Globin Clusters and Their Impact on Phenotypic Severity in Thalassemia and Sickle Cell Disease.

J Clin Med · 2026 · PMC12941110 · PMID 41753033

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

highly significantno p-value reported

Polymorphisms within the BCL11A gene, predominantly intronic SNPs (rs4671393; rs11886868), constitute a highly significant quantitative trait locus, influencing adult HbF levels [ 19 , 40 , 55 ].

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.