highly significantp ≤ 0.05
The analysis of variance (ANOVA), with non-significant parameters incorporated into the residues, for the composite central rotational design (CCRD) models summarized in Table S2 in the Supplementary Materials , showed that all models were highly significant ( p ≤ 0.05) and provided a good fit to the experimental data, with R 2 values ranging from 89.02% to 93.02%.