In Vitro Evaluation of Colistin-Meropenem Activity Against XDR and PDR Carbapenemase-Producing <i>Klebsiella pneumoniae</i> and <i>Acinetobacter baumannii</i>.

Although true synergy (ΣFIC ≤ 0.50) was observed in 35.5% and 40.7% ( Appendix A , Table A2 ) of CRKP and CRAB isolates, respectively, the combination showed a highly significant ( p -value < 0.001) reduction in the MICs of MEM (range = 0.5–128 μg/mL) and COL (range = 0.125–8 μg/mL) when applied in combination compared to the MIC of each single drug (MEM: 4–256 μg/mL, COL: 0.125–512 μg/mL) ( Table 2 ).

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