highly significantp < 0.001
In mice challenged with KP45147, KPC-Pal + meropenem conferred 90% survival, surpassing KPC-2 + meropenem (70%), KPC-Pal alone (70%), Pal + meropenem (40%), and PBS + meropenem (0%); the difference between KPC-Pal + meropenem and PBS + meropenem was highly significant ( p < 0.001).