Sex-based multiomics analysis uncovers metabolic and molecular mediators linking MASH and atherosclerosis.

JHEP Rep · 2026 · PMC12950431 · PMID 41777553

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a mild trendno p-value reported

Mmp12 was the most significantly upregulated gene across all our cohorts (except for a mild trend in the female C57BL/6J model), but was more significantly increased in males, while Trem2 was more significantly increased in females ( Fig. 7 B,D,F,I,K,M), which was consistent across our additional mouse models ( Fig.

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