Most importantly, the direction of change for all VIP sphingolipids aligned perfectly with the predictions of the “sphingolipid rheostat” theory: in responders, the pro-survival sphingolipid S1P was significantly downregulated, SPH showed a decreasing trend, while pro-apoptotic ceramides were generally upregulated, with CER(d18:1/26:0) showing a significantly greater increase compared to non-responders ( Figure 8D ; detailed statistical data in Supplementary Table 15 ).
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Plasma Sphingolipid Profiling Predicts Radiosensitivity in Hepatocellular Carcinoma.
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