Behavioral deficits and exacerbated neural and hemodynamic odor responses during lifespan of a mouse model of late onset Alzheimer's disease expressing humanized APOEε4 and Trem2*R47H.

All groups on all days showed highly significant sucrose preference (1-tailed unpaired t-test, p < 0.001).

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APOE4.TREM2 mice show an increasing trend of vascular hyperresponsiveness to odor stimuli with age, while the WT mice show no significant BV changes with increasing age in the 1SD-based ROI responses ( Figure 12A , APOE4.TREM2: −5.5% AUC /months, with an r 2 = 0.29; WT: +2.3% AUC /months, and r 2 = 0.09).

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Genotype was marginally significant [ F (2,50) = 3.49, p = = 0.068].

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