Safety pharmacology and toxicology of a novel nitroimidazooxazole antitubercular agent in SD rat and Beagle dogs.

In male dogs, the NOAEL was determined to be 15 mg/kg/day, a discrepancy primarily attributed to a slight trend toward Corrected QT interval (QTc) prolongation at higher doses (60 and 300 mg/kg/day) to which males exhibited greater cardiovascular sensitivity.

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