NFATc1 and NFATc2 regulate glucocorticoid resistance in pediatric T-cell acute lymphoblastic leukemia through modulation of cholesterol biosynthesis and the WNT/β-catenin pathway.

5-7 Interestingly, among the top drivers we identified the GC nuclear receptor subfamily 3 group C member 1 ( NR3C1 ), already known to be associated with GC response, as well as NFATc2 and NFATc1 , although the latter at the limit of significance ( Figure 1A ).

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