Inflammation-induced impairment of synaptic plasticity accelerates atherosclerosis co-depression disease: insights from bioinformatics analysis and transcriptomics.

Cell Biosci · 2026 · PMC12952031 · PMID 41622251

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a decreasing trendno p-value reported

Additionally, in vitro experiments using the hippocampal neural cell line HT-22 demonstrated a decreasing trend in Shank2 protein levels under the influence of three different concentrations of IL-1β, confirming the negative impact of inflammation on synaptic proteins.

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