Design, synthesis and anticonvulsant evaluation of novel 2,4,5-trichlorobenzenesulfonate-based dihydrothiazoles supported by <i>in vivo</i> and <i>in silico</i> studies.

Among the N -cyclohexyl analogues, compound 3c (C-4 = unsubstituted phenyl) emerged as the standout derivative, providing complete protection in the 6 Hz model at both 100 and 150 mg kg −1 (identical to levetiracetam) and full protection against hind-limb extension and mortality in the PTZ model at 150 mg kg −1 , with 75% protection and highly significant prolongation of all seizure phases at 100 mg kg −1 .

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