In line with a putative implication of TDG in the control of ferroptosis sensitivity in human cancer cells, analysis of the correlation between TDG expression and protein levels through interrogating proteomics data obtained in cancer cell lines ( https://depmap.org/portal/interactive/custom_analysis ) revealed that highly significant correlations were observed for ferroptosis-related proteins (Fig. 6H ), such as the pro-ferroptotic proteins MVP, FOSL1, and CTSB [ 88 – 90 ], or the anti-ferroptotic protein CD44 [ 91 ].
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TDG orchestrates ATF4-dependent gene transcription during retinoic acid-induced cell fate acquisition.
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