Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.

Nat Immunol · 2026 · PMC12956583 · PMID 41540265

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Further, there was a positive trend among the remission and non-remission groups between baseline COMP + cell abundance and DAS28-ESR at 12 months, highlighting the link between COMP + cell abundance and longer-term disease activity (Extended Data Fig. 4g ).

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