Multi-dimensional evidence establishing the causal association between metabolic syndrome and gout and the molecular mechanisms of comorbidity.

Front Immunol · 2026 · PMC12956786 · PMID 41789074

Europe PMC DOI

hedged sentence

0.4240

closest p · 8.5× alpha

0.4240

boldest claim

The sentences

highly significantP = 4.24×10 - 1not close (p > 0.1)

3.8 Common genetic architecture and molecular mechanisms of metabolic syndrome and gout LDSC analysis revealed highly significant positive genetic correlation between metabolic syndrome and gout at the genome-wide level (rg=0.321, P = 4.24×10 - 1 5 ), indicating that the two diseases share a large number of identical genetic risk variants, providing a genetic explanation for their comorbidity.

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