Expanding Access to Genome Sequencing: Higher Diagnostic Yield in Self-Referred Participants From the CincyKidsSeq Study and Implications for Hybrid Models of Genetic Service Delivery.

Clin Genet · 2026 · PMC12958015 · PMID 41204439

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

close to significancep = 0.0590so close (0.05 < p ≤ 0.1)

The number of HPO terms was close to significance ( p = 0.0590).

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a slight trendno p-value reported

We noticed a slight trend that patients in the self‐referred cohort were more likely to have higher frequency ranked HPO terms related to mental health (anxiety, depression, ADHD) and functional symptoms (reflux, hypermobility, muscle weakness) than physician‐referred patients.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.