MERS-CoV and SARS-CoV-1 proteins inhibit the IFN-α JAK/STAT pathway of epithelial cells, via IFN-λ-induced USP18.

Front Immunol · 2026 · PMC12960643 · PMID 41798916

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0.0600

closest p · 1.2× alpha

0.0600

boldest claim

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near significancep=0.06so close (0.05 < p ≤ 0.1)

Induction of IFN-λ3 upon MERS-CoV-nsp2 expression was near significance (p=0.06) ( Figure 1D ); whereby IFN-λ3 was not impacted by MERS-CoV-nsp5 ( Figure 1D ).

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