Alkaline Phosphatase Supplementation During Hypothermic and Normothermic Machine Perfusion Improves Metabolic Dysfunction in a Porcine Model of Donor Kidney Preservation.

Transplant Direct · 2026 · PMC12962581 · PMID 41799024

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0560

boldest claim

The sentences

marginally statistically significantP = 0.056so close (0.05 < p ≤ 0.1)

After NMP, kidney metabolites, measured with liquid chromatography–mass spectrometry, were analyzed by PCA (Figure 4 C and D) as a post hoc analysis, which demonstrated a marginally statistically significant difference in group clustering between the ALP and control groups (PCA, P = 0.056) based on the glycolytic metabolites glucose, glucose-6-phosphatse, pyruvate and lactate and a significant difference in group clustering in mitochondrial metabolites (PCA, P = 0.028) based on the metabolites of acetyl-CoA, citric acid/isocitrate, glutamate and lactate (see Figures S6–S9 , SDC , https://links.lww.com/TXD/A843 ).

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borderline significantno p-value reported

This was accompanied by a borderline significant PCA analysis showing lower levels of glycolytic metabolites in the ALP-treated group, which could be consistent with less metabolic shunting towards (anaerobic) glycolysis.

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