TCL1A mediates DNA methylation defects in recurrent hydatidiform mole with NLRP7 pathogenic variants.

Nat Commun · 2026 · PMC12963396 · PMID 41786744

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may be significantno p-value reported

Although there may be significant differences in mechanisms and patterns between humans and mice, mouse maternal factors essential for de novo methylation in oocytes, including DNMT3A, DNMT3L, KDM1A, KDM1B, SETD2, HDAC1/HDAC2, SIN3A, CFP1, SALL4, and HIRA, have been identified 29 , 30 .

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