Imidazole as a Pendant Reactivation Ligand Increases Efficacy Scope for Reactivation and Resurrection of Organophosphorus-Inhibited/Aged Cholinesterases by Quinone Methide Precursors.

ACS Chem Neurosci · 2026 · PMC12964352 · PMID 41712538

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an interesting trendno p-value reported

These data indicate an interesting trend in which the 4-position ( para ) shows overall better broad-scope efficacy in both reactivation of OP-inhibited and resurrection of OP-aged AChE while the 5-position shows overall better reactivation, while not being able to perform resurrection.

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