Repurposing metformin as a dual-function agent to combat E. coli-induced mastitis: Mechanistic insights into biofilm dispersion and AMPK/SIRT1-mediated NF-κB inhibition.

PLoS Pathog · 2026 · PMC12965556 · PMID 41790864

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

a decreasing trendp = 0.07so close (0.05 < p ≤ 0.1)

At the molecular level, analysis of the mammary NAD+ level revealed that while the absolute NAD+ content showed a decreasing trend in the EC group (p = 0.07), the functional NAD + /NADH ratio was significantly reduced.

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