Reducing Early-Life Smoke Exposure as a Preventive Strategy for Pediatric Multiple Sclerosis: Results from the PEDIGREE Study.

Neurol Ther · 2026 · PMC12965922 · PMID 41706361

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

almost significantp = 0.059so close (0.05 < p ≤ 0.1)

Smoking habit over the 3 months prior to pregnancy also did not show a significant association, though an almost significant result was observed after adjustment (adjOR 3.75, 95% CI 0.95–14.76, p = 0.059).

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a trend towards significanceno p-value reported

Nonetheless, a trend towards significance with maternal smoking habit suggests that with a larger sample size, these findings might reach statistical significance.

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