slight significancep = 0.025
In multivariable logistic regression analysis including geographic variables only, variable “[number of] Distinct states” was strongly associated with higher odds of success (OR = 1.04, p = 4.57e-36), while trials conducted in more rural settings had lower odds of success with slight significance (OR = 0.86, p = 0.025) as shown in Supplementary Table S6.