Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival.

In ALS‐only analysis, there were modestly significant associations with disease duration for estrone in males ( R = 0.14, p ‐value = 0.018), 11‐ketotestosterone in females ( R = −0.25, p ‐value < 0.001), and 11‐hydroxyandrostenedione in females ( R = −0.27, p ‐value < 0.001) (Figure S6 ).

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