Diagnostic challenges of histidine-rich protein 2-based rapid diagnostic tests due to pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria in Tanzania.

McNemar’s test confirmed that the difference in individual-level positivity between RDT and qPCR was highly significant ( P < 0.001), suggesting that reliance on RDTs alone may underestimate true infection prevalence, particularly in low-density or asymptomatic infections.

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