APP E590D mutation increases generation of Aβ and Aη peptides and exacerbates tauopathy.

NPJ Dement · 2026 · PMC12971483 · PMID 41816611

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highly significantno p-value reported

Normalized to total full-length APP, we detected a highly significant ~60% reduction in surface APP695 E590D compared to surface APP695 WT (Fig. 2C, D ).

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