Mature tertiary lymphoid structures tumor microenvironment-based risk model to assess patients with pancreatic ductal adenocarcinoma.

Firstly, as the source of this signature, the brown module’s gene set showed a highly significant enrichment in core processes such as the B cell receptor (BCR) signaling pathway (P=1.09e−24) and B cell activation (P=4.07e−17) in detailed pathway analysis.

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