Cross-species hepatic transcriptomics identify conserved immune-metabolic reprogramming in acute-on-chronic liver failure progression.

Front Immunol · 2026 · PMC12971639 · PMID 41816324

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an increasing trendno p-value reported

Independent validation by RT-qPCR of six monocyte/macrophage-related genes ( MMP12 , TREM2 , ITGA2 , CAPG , F13A1 , and LGALS3 ) and western blot analysis of two markers ( TREM2 and CCR2 ) in clinical and murine cohorts recapitulated these expression trends, demonstrating an increasing trend during ACLF progression ( Figures 7C–E ).

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