A compass in the challenge: the CALLY index as a prognostic biomarker in advanced cholangiocarcinoma treated with chemoimmunotherapy: a retrospective propensity score-matched cohort study.

Front Immunol · 2026 · PMC12971696 · PMID 41816341

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These findings indicated that patients with a high CALLY index experienced a consistently slower decline in HRQoL throughout treatment, with this protective effect reaching borderline significance as early as week 12 and becoming statistically significant from week 18 onward ( Table 2 ). 4 Discussion The management of advanced CCA remains a clinical challenge.

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