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GNPAT promotes immunosuppression in hepatocellular carcinoma by activating the plasmalogen-PPARγ pathway to drive M2 macrophage polarization.

Front Immunol · 2026 · PMC12971976 · PMID 41816340

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an increasing trendno p-value reported
Such an epidemiological transition has been strongly linked to an increasing trend in obesity and established MASLD as the fastest-growing etiology leading to liver transplantation for HCC ( 1 , 2 , 29 – 31 ).

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